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KMID : 0369819820120030055
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Jorunal of Korean Pharmaceutical Sciences
1982 Volume.12 No. 3 p.55 ~ p.63
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Polymorphism of Sulpiride and Its Pharmaceutical Applications (Ⅲ) ; Dissolution Kinetics of Sulpiride Polymorphs
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이민화/Lee MH
김길수/Kim KS
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Abstract
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The dissolution kinetics for polymorphs of sulpiride, the effect of polyethylene glycol 4000 on the dissolution kinetics of sulpiride polymorphs and the dissolution rate difference between the tablets of polymorph form I and form II were investigated. The results could be summerized as followings: 1. The dissolution rates of two polymorphs of sulpiride were significantly different and the thermodynamic parameters calculated from dissolution kinetics were as follows; transition temperature 98?C, enthalpy change, -2.108 kcal/mole, free energy change, -783 cal/mole (31.0?C). 2. The dissolution rates of the two polymorphs of sulpiride containing polyethylene glycol 4000 were significantly diefferent in 0.01N HCl but the effect of polyethylene glycol on the dissolution rates of two polymorphs was not significant at low concentration of polyethylene glycol 4000. The study on the effect by stirring speed showed that at lower stirring speed the promotion rate of dissolution of polymorph form I is greater than that of form II. 3. In the case of tablets the dissolution rates of polymorph form I of sulpiride was two fold as compared with the results obtained from form II.
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